. The diseases of infancy and childhood : designed for the use of students and practitioners of medicine. Fig, 194.—Cast of the hand of a boy cretin, aged four years. Flat and spade-like inform; it shows also the thickened and hypertrophied hypothenar Fig. 195.—Cretin, type, aged four years. 710 DISEASES OF LYMPH XODES. DUCTLESS GLAXDS AXD BLOOD Morbid Anatomy.—There are cases of sporadic cretinism in whichthe thyroid gland is absent. It has not developed in fetal life and isnot found at autopsy. In other cases there is found at autopsy asmall atrophied gland which is
. The diseases of infancy and childhood : designed for the use of students and practitioners of medicine. Fig, 194.—Cast of the hand of a boy cretin, aged four years. Flat and spade-like inform; it shows also the thickened and hypertrophied hypothenar Fig. 195.—Cretin, type, aged four years. 710 DISEASES OF LYMPH XODES. DUCTLESS GLAXDS AXD BLOOD Morbid Anatomy.—There are cases of sporadic cretinism in whichthe thyroid gland is absent. It has not developed in fetal life and isnot found at autopsy. In other cases there is found at autopsy asmall atrophied gland which is sclerosed and much reduced in cases have been published as following the infectious , there are cases with goiter. The changes in the thyroid, whenit is found in sporadic cretinism, have been described by is an increase of connective tissue. The parenchjTna is replacedby small and large irregularly shaped cells, which are granular andunlike the normal tissue. Some of the acini are almost solid; othersare cystic and filled with colloid material. The cells may containvacuoles; their nuclei may show karyorrhexis. The nuclear changesare characteristic of degenerative processes. Some of the acini arereplaced by connec
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