The malarial fevers, haemoglobinuric fever and the blood protozoa of man . sion. Asamatter of fact, both forms of division occur, equal longitudinal division beingmost commonly observed; but not infrequently an organism may be observedin which the splitting off of the minute spirillar-like forms described byLeishman is occurring. The latter forms are at first devoid of a flagellum,but one is developed rapidly and the organism becomes very actively motile. THE BLOOD PROTOZOA OF MAN. 417 The forms resulting from equal longitudinal division are at first pear-shapedand broad, but soon elongate and
The malarial fevers, haemoglobinuric fever and the blood protozoa of man . sion. Asamatter of fact, both forms of division occur, equal longitudinal division beingmost commonly observed; but not infrequently an organism may be observedin which the splitting off of the minute spirillar-like forms described byLeishman is occurring. The latter forms are at first devoid of a flagellum,but one is developed rapidly and the organism becomes very actively motile. THE BLOOD PROTOZOA OF MAN. 417 The forms resulting from equal longitudinal division are at first pear-shapedand broad, but soon elongate and become actively motile, much more so thanwere the parent bodies at the time of division; the blepharoplast, from whicharises the flagellum, is situated anteriorly, while the nucleus is at or near thecenter of the body. After the formation of the flagellated forms no furtherdevelopment occurs in cultures, and the organisms soon perish. Theflagellated forms of the Leishman-Donovan body appear in cultures betweenthe third and sixth day after inoculating the culture U-J-t IrJ ,l < Fig. 26.—Leishmania donovani. (After Leishman.)1-3, Kala-azar parasites as observed in man. At 3 is seen a large mononuclear cell contain-ing four parasites; 4-14, Leishmania donovani as observed in cultures (cultural forms). At12 and 13 are seen parasites dividing into the spirochete forms described by Leishman. Multiplication.—In man, Leisliniania-donovani multiplies in two ways: bysimple fission, binary in character, and by multiple fission. In the former thenucleus first divides into two, quickly followed by the division of the blepharo-plast (micronucleus) into two portions, after which the body of the parasitedivides longitudinally into two equal portions, each of which contains a nucleus27 4l8 THE BLOOD PROTOZOA OF MAN. and a blepharoplast. When multiple fission occurs, the parasite becomesnearly twice as large as normal, the nucleus and blepharoplast divide intothree, four or
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