Rabies Virus, LM
This micrograph depicts the histopathological changes associated with rabies encephalitis prepared using an H&E stain. Note the perivascular cuffing due to the perivascular accumulation of inflammatory cell infiltrates, lymphocytes and polymorphonuclear leukocytes. The virus infects the central nervous system, causing encephalopathy and ultimately death. Rabies virus belongs to the order Mononegavirales, viruses with a nonsegmented, negative-sense single-stranded RNA ((-) ssRNA) genomes. Early symptoms of rabies in humans are nonspecific, consisting of fever, headache, and general malaise. As the disease progresses, neurological symptoms appear and may include insomnia, anxiety, confusion, slight or partial paralysis, excitation, hallucinations, agitation, hyper-salivation, difficulty swallowing, and hydrophobia (fear of water). Death usually occurs within days of the onset of symptoms.
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Photo credit: © Photo Researchers / Alamy / Afripics
License: Licensed
Model Released: No
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