The British journal of dermatology . destroyed as toseriously damage the protein mass, the is anti-complementarybecause nothing added can restore the balance; it only furthers theprecipitation. 86 THE RATIONALE OF THE WASSERMANN KEACTION. A syphilitic serum can give a negative wlien the balancebetween the electrolytes and the protein mass is a normal one; whenthe loss of electrolytes reduces the particles to the neutral or iso-electric point; and when there is sufficient albumin to counteract anysurface or substantive change in particles which have become throughthe change globul
The British journal of dermatology . destroyed as toseriously damage the protein mass, the is anti-complementarybecause nothing added can restore the balance; it only furthers theprecipitation. 86 THE RATIONALE OF THE WASSERMANN KEACTION. A syphilitic serum can give a negative wlien the balancebetween the electrolytes and the protein mass is a normal one; whenthe loss of electrolytes reduces the particles to the neutral or iso-electric point; and when there is sufficient albumin to counteract anysurface or substantive change in particles which have become throughthe change globulin or lipoid-globulin. The , as can be seen now, is a cyclical reaction in which theextreme degree of positivity is a negative reaction—anti-comple-mentary reactions being more commonly met with in experimentalwork. The changes serum protein undergo are likewise —^ globulin —^ lipoid-globulin -^ albumin. ^GLobalin Ax + +. lit, 3 / y^ \^ ^ Globii liji — ^ ^ ^ globulin Albumin - * \lbuminilobulin. Non eleef-rolytie •rroiytie-gloDulin The above diagram (Ciicle 4) puts the problem into a nutshell,as it not only shows the cyclical nature of the , but also it mapsout the paths followed by a conductor and condenser in a rabbit, andthe influence both have on the in man. Stages 1-4 representearly syphilis, and stages 4-1 late syphilis. The path traversedby a serum in the course of syphilis, which is also the pathtraversed by a conductor in a rabbit, is depicted outside thecircle. The path traversed by a condenser is depicted insidethe circle. Take stage 6 as an example: in late syphilis (outside thecircle) the reaction is negative, and a single injection of a conductorhas passed the extreme positive stage to give a negative Inboth cases the reaction is negative, because the neutral or iso-electricpoint has been reached by the protein particles. In both cases a THE RATIONALE OF THE WASSEBMANN REACTION. 87 single injection of a
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Keywords: ., bookcentury1800, bookdecade1880, booksubjectsyphilis, bookyear188
