. The thyroid gland in health and disease. Fig. 53.—Large congenital goitre in prematurely-born kid ; experimentally-produced. Mother fed on cultures of fsecal bacteria before and during pregnancy. fed infants has been found. [1.] It is interesting to note that thisfigure corresponds very closely to that found in experimentally-produced cases in rats (63 per cent.). 121 122 CONGENITAL GOITRE In such villages the percentage of abortion among women,and the infant mortality, are very high, so that the actual per-centage of cases born with goitre is probably considerably higherthan 60 per cent. In
. The thyroid gland in health and disease. Fig. 53.—Large congenital goitre in prematurely-born kid ; experimentally-produced. Mother fed on cultures of fsecal bacteria before and during pregnancy. fed infants has been found. [1.] It is interesting to note that thisfigure corresponds very closely to that found in experimentally-produced cases in rats (63 per cent.). 121 122 CONGENITAL GOITRE In such villages the percentage of abortion among women,and the infant mortality, are very high, so that the actual per-centage of cases born with goitre is probably considerably higherthan 60 per cent. In villages, on the other hand, where the endemicity of thedisease is lower, congenital goitre is not so common. The mothers of children born with congenital goitre are oftenmyxoedematous to some extent. They commonly suffer fromtetany. -».*a!i-:V!* .rv^^::;^-. Fig. 54.—Section of thyroid from a case of congenital goitre in 30-day-olcl ratParents fed on fiscal filtrate before and during pregnancy. Note great prolifera-tion of parenchyma. Very small vesicles ; little colloid in vesicles. Invasionof gland by fibroblasts. X. 90. Congenital goitres are usually uniform enlargements of smallsize, which tend to disappear spontaneously a few months afterbirth. In animals in endemic areas, in which congenital goitreis also found, the disappearance of the swelling after birth iscommonly very rapid. Occasionally, however, the goitre maybe very large (fig. 53), or so large as to impede delivery. Congenital goitre is much more commonly found in the poorand ill-nourished classes. It is rare in cretins. Indeed, in my series of 203 cretins onlytwo cases of goitre were found before the age of three years. CONGENITAL GOITRE 123 The histological features of congenital goitre resemble thoseof other hyperplasias of the thyroid. There is an enormousover-product
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