Practical pathology; a manual for students and practitioners . um fever, or 766 MICROSCOPIC PARASITES Kala-azar (Assam), is a very chronic, but ultimately fatal, form offebrile ansemia. During life it is characterised by marked bloodless-ness, accompanied by a very definite fall in the number of leucocytes,greater in proportion than the fall in the red-blood corpuscles, which,however, is considerable. Ulcerations of the cutaneous and mucoussurfaces are fairly common, and dropsy is often present, along withenlargement of the liver and spleen. Leonard Rogers notes thatthese latter, along with ul
Practical pathology; a manual for students and practitioners . um fever, or 766 MICROSCOPIC PARASITES Kala-azar (Assam), is a very chronic, but ultimately fatal, form offebrile ansemia. During life it is characterised by marked bloodless-ness, accompanied by a very definite fall in the number of leucocytes,greater in proportion than the fall in the red-blood corpuscles, which,however, is considerable. Ulcerations of the cutaneous and mucoussurfaces are fairly common, and dropsy is often present, along withenlargement of the liver and spleen. Leonard Rogers notes thatthese latter, along with ulceration of the lower part of the smallintestine and the colon and proliferation of the cells of the bonemarrow, are the principal pathological lesions met with at the post-mortem examination. Make a section of the swollen spleen, and from the freshly cutsurface make films on a slide or cover-glass (§ 152), and stain (§ 153). (xiooo).—Lying free or grouped in the large endothelial cellsof the spleen are deeply stained points, round, oval or cockle-shaped. Fig. 267.—Kala-azar. Scraping from spleen. Donovan-Leishman?bodies. Stained by Leishmans method. ( x 1000.) a. Large endothelial cell of splenic pulp containing numerous Donovan-Leishman bodies,h. Similar bodies lying free between the cells, bodies, measuring from 3-5 to 2-5 /x or even less in diameter. Theprotoplasm of these bodies—the so-called Donovan-Leishman bodies(after the observers who first described them)—stains somewhat un- I DONOVAN-LEISHMAN BODIES—SPIROCHMTA PALL/DA 767 equally of a light blue tint. Embedded in this, usually with a lightlystained area between them, are two very deeply stained corpuscles ofunequal size. These take on a violet colour with Leishmans stain,corresponding to that taken on by the nuclei of the surroundingcells. The larger of these corpuscles is not quite so deeply stainedas the smaller; it is rounded, oval, conical, or sometimes almostdumb-bell shaped. It is usually seen at o
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