. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. AMPUTATIONAL WOUND HEALING IN MICE 549 surface, the left .side representing the dorsal surface. The palmar or volar sur- face of the mouse digit is characterized by the absence of hair follicles and by a thick epithelium and dermis, while the dorsal epithelium possesses many hair follicles and is thinner than the volar. When a digit is sectioned horizontally the follicle distribution permits one to determine the exact position of the section. Amputation in this case was made through the mid-diaphyseal region of phalanx 2, an
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. AMPUTATIONAL WOUND HEALING IN MICE 549 surface, the left .side representing the dorsal surface. The palmar or volar sur- face of the mouse digit is characterized by the absence of hair follicles and by a thick epithelium and dermis, while the dorsal epithelium possesses many hair follicles and is thinner than the volar. When a digit is sectioned horizontally the follicle distribution permits one to determine the exact position of the section. Amputation in this case was made through the mid-diaphyseal region of phalanx 2, and it is possible to observe the retracted extensor and flexor tendons on both sides of the bone. The early hours of wound healing after amputation are characterized, accord- ing to Arey (op. eit.) and Robbins (op. eit.) by provisional closure with a blood clot and subsequent inflammation. Six hours after amputation (Fig. 1) the wound. FIGURE 2. Photomicrograph of longitudinal section from a digit (Case MCS 129, L-2-III), fixed one day after amputation. A continuous layer of epithelial cells covers the amputation surface and it separates from the stump the large scab composed of clotted blood and various tissue debris. Inflammation at this stage has spread into the stump, and large masses of leukocytes have accumulated around the cut end of the bone (150 X). area is covered by a solidified blood clot beneath which polymorphonuclear leuko- cytes are agglomerating. By one day (Fig. 2, Case MCS 129, L-2-III), the ex- tent of necrosis as indicated by the area of leukocytic activity has spread deeper into the tissues, particularly around the cut end of the bone. The polymorpho- nuclear leukocytes that characterize the early stages of inflammation begin to die off and they become extruded with part of the scab (Fig. 2). Subsequently mono- cytes and lymphocytes from the blood and young macrophages from the tissues identifiable in large numbers for at least three days replace the polycy
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
