Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . iently long to develop fibroid changes in the intertubular connective tissue. When the kidney is consideredas a mucous membrane, the resemblance between the changes seen inthe submucosa after protracted inflammations of the mucous mem-branes and the interstitial changes observed in the kidney subsequentto a prolonged inflammatory lesion of the tubules become quite evident. Chronic diffuse nephritis is almost invariably attended by edema may be slight or quite marked. It is
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . iently long to develop fibroid changes in the intertubular connective tissue. When the kidney is consideredas a mucous membrane, the resemblance between the changes seen inthe submucosa after protracted inflammations of the mucous mem-branes and the interstitial changes observed in the kidney subsequentto a prolonged inflammatory lesion of the tubules become quite evident. Chronic diffuse nephritis is almost invariably attended by edema may be slight or quite marked. It is usually greater inthe typic large white kidney than when the organ is small and is also more common in cases of large white than small whitekidney. Retinal lesions are less frequent than in the chronic inter-stitial nephritis. Hypertrophy of the heart, except in children, is rare,although with beginning contraction the blood-pressure is slightlyelevated and the muscle of the heart. [)articularly of the left ventricle,usually increased. A marked secondary anemia is practically Fig. 321.—Kidney, ChronicDiPPCSF. Nephritis. ( normal si/x-. Grossspecimen treated .4. Fatlyareas in the cortex largelyrestricte<l to areas, of laby-rinth. 652 SPECIAL PATHOLOGY. Changes in the urine accompanying chronic diffuse nephritis: Usu-ally the urine is diminished in quantity, and sometimes the secretionfor the twenty-four hours does not exceed 250 In other casesthe daily output approximates the normal, although a careful studycommonly demonstrates that the solids fall short. The specific gravitydepends more upon the quantity than upon other factors. Usuallyit is lower than in health. The quantity of albumin varies, but is com-monly large; occasionally the urine contains more than the blood. Theurea excretion is practically always below the normal, and is less influ-enced by diet than is the secretionfrom unaltered kidneys. The ot
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