Alexander's Illness at the Cydnus River and the Death of Sisinnes; Livre des fais d'Alexandre le grant, about 1470-1475. Additional Info: Alexander the Great emerges naked from the Cydnus River, whose cold waters have made him ill. Seen later in his tent on the left, Alexander accepts the treatment of his physician Philip, even though Philip has been accused of plotting Alexander's demise. In the background, the Persian Sisinnes is beheaded for treason: He had failed to report his knowledge of an assassination attempt against Alexander.

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