The chemist and druggist [electronic resource] . significantly withdisability (causing immobility)and cumulative but not currentsteroid dose. This finding challenges theview that low-dose steroids arerelatively safe in RA. Furtherevidence comes from a Dutchstudy of 40 patients with RAtaking gold, who wererandomised to or placebo. Over 20weeks, there was little changein bone mass in those takingplacebo. By contrast, bone massin the spine decreased by 8 percent in patients takingprednisone. When treatmentwas withdrawn, bone densityrecovered by only about 5 percent in the foll
The chemist and druggist [electronic resource] . significantly withdisability (causing immobility)and cumulative but not currentsteroid dose. This finding challenges theview that low-dose steroids arerelatively safe in RA. Furtherevidence comes from a Dutchstudy of 40 patients with RAtaking gold, who wererandomised to or placebo. Over 20weeks, there was little changein bone mass in those takingplacebo. By contrast, bone massin the spine decreased by 8 percent in patients takingprednisone. When treatmentwas withdrawn, bone densityrecovered by only about 5 percent in the following six months. Treatment with prednisonequickly and significantlyimproved symptoms andfunctional capacity, but itseffects on bone mass weresimilarly rapid. Taken together, these studiesshow that steroids must be usedwith great care, particularly inpost-menopausal women, andthey emphasise the need tomaintain mobility and toconsider HRT for women at and Rheumatism 1993;36: 1510-6 & Annals of InternalMedicine 1993; 119: 963-8. Research Digest is a regularseries written by druginformation specialist SteveChaplin MRPharmS, looking atthe current developments inmedicine Chemist & Druggist 29 JANUARY 1994 Talking tactics ontoxic shock syndrome Although public awareness of toxic shocksyndrome is high, there is still confusion about its causes and who can be Mac Donald describes the symptoms,treatment and prevention of toxic shocksyndrome and dispels some of the mythswhich surround it Toxic shock syndrome (TSS) is amuch talked about, highlyemotive condition. We haveonly been aware of its existencesince 1980, when it was firstdefined in the US. However, it is unlikely thatmany pharmacists, or womenfor that matter, could sayexactly what it is, what thecommon symptoms are, andwhat can be dome about it. Most people associate thecondition with menstruationand, indeed, almost half thecases that have been reportedarise from this. The remainderare associated w
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