. General surgical pathology and therapeutics, in fifty-one lectures .. . e more accurately the or-ganization of the thrombus. The importance of this process is ratherextensive; a point on which you cannot at present judge well, butwill hereafter be in a position to estimate fully, when we come totreat of diseases of the vessels. From my investigations up to the present time, I do not think Idare retract the assertion that coagulated fibrine may, by aid of cells,be transformed into connective-tissue intercellular substance, althoughI cannot decide whether this be due to true metamorphosis, or
. General surgical pathology and therapeutics, in fifty-one lectures .. . e more accurately the or-ganization of the thrombus. The importance of this process is ratherextensive; a point on which you cannot at present judge well, butwill hereafter be in a position to estimate fully, when we come totreat of diseases of the vessels. From my investigations up to the present time, I do not think Idare retract the assertion that coagulated fibrine may, by aid of cells,be transformed into connective-tissue intercellular substance, althoughI cannot decide whether this be due to true metamorphosis, or to agradual substitution of cell protoplasm for disappearing fibrine. Somehave attempted to refer the origin of the cells, which appear in con- 124 SIMPLE INCISED WOUNDS OF THE SOFT PARTS. etantly-increasing numbers in the thrombus, to the wall of the vessel;the arteries, as well as the veins, are coated with a lining of epithe-lium, which to some extent represents the innermost lamella of thetunica intima. These epithelial cells and the nuclei of the striated Fig. Longitudinal section of the ligated end of the crural artery of a dog, fifty days after ligation;the thrombus is injected; a a, tunica intima and media; b b, tunica adventitia. Magnified40 diameters. lamellae of the intima have been claimed a priori by some authors, sothat they could let new cells be formed from them, and grow into thethrombus; in his last work, Thiersch also inclines to this view. Iacknowledge that I myself formerly strongly combated the supposi-tion that the blood could of itself become organized to connectivetissue with vessels ; but from examinations of transverse sections ofthrombosed arteries, I am satisfied of its correctness. After havingabandoned the idea of proliferation of stable tissue-cells in inflamma-tion, we can no longer talk of a proliferation of the intima in the oldsense. But whence come, then, these newly-formed cells ? I have nodoubt that they originate from the white blood
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