. Electron microscopy; proceedings of the Stockholm Conference, September, 1956 . Fig. 1. Clusters of small B-granules in an A-granule. The very characteristic C-granule with its many concentric membranes is also seen. Two tubercle bacilli (tbb) are seen. The picture is supposed to demonstrate an early stage of cell destruction. Magnification 46,000. arranged in parallel rows. The C-granules are some- times more or less covered by a black osmiophilic homogeneous substance. The different types of granules just described have been recorded in the same section (fig. 1) as well as some others whic
. Electron microscopy; proceedings of the Stockholm Conference, September, 1956 . Fig. 1. Clusters of small B-granules in an A-granule. The very characteristic C-granule with its many concentric membranes is also seen. Two tubercle bacilli (tbb) are seen. The picture is supposed to demonstrate an early stage of cell destruction. Magnification 46,000. arranged in parallel rows. The C-granules are some- times more or less covered by a black osmiophilic homogeneous substance. The different types of granules just described have been recorded in the same section (fig. 1) as well as some others which according to their ultrastructure (number of concentric membranes and granulated centers etc.) very possibly could be intermediate stages. The different granules and vacuoles are supposed to be stages in the degeneration of cells, where "A-, B-, and C-granules" are found in the early stages. The black granules could be intermediate products, which later on are dissolved leaving vacu- oles in the eel I. (The eel Is containing the black granules are In this case supposed to be macrophages.) The degeneration is believed not to be absolutely specific for the tuberculous inflammatory reaction. The reason for this conclusion is that a very few opaque granules of about the same size can be seen in normal lung tissue cells and \o a cerlaiii extent have also been observed in lung tissue from pneumo- coccus-infccted mice. This experiment, howe\er. has shown a distinct increase in the number of the characteristic black granules. My interpretation is, that normally cells are to a certain extent degenerating and dying. In the infected tissue, however, where the infecting agent is localized in the cell proper, this degeneration is proceeding rapidly and intensively thus giving very obvious alterations.
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