Manual of pathological anatomy . matter. We are inclined to thinkthe latter is not unfrequently thecase, and for the following reasons:—(1) It seems quite impossible to be-lieve that the very considerable quan-tity of black matter often found inthe interlobular tissue of the lungs-of old persons, should have proceededfrom local congestions and extravasa-tions, especially when there is notrace of previous inflammatory ac-tion. (2) We are well acquaintedwith the changes which hsematinedoes undergo in the splenic tissue andin the renal tubules, when blood has escaped out of the vessels r andwe ha
Manual of pathological anatomy . matter. We are inclined to thinkthe latter is not unfrequently thecase, and for the following reasons:—(1) It seems quite impossible to be-lieve that the very considerable quan-tity of black matter often found inthe interlobular tissue of the lungs-of old persons, should have proceededfrom local congestions and extravasa-tions, especially when there is notrace of previous inflammatory ac-tion. (2) We are well acquaintedwith the changes which hsematinedoes undergo in the splenic tissue andin the renal tubules, when blood has escaped out of the vessels r andwe have far most commonly observed the colour of the granulesto be an orange or reddish yellow. The same is the case inthe remarkable production of yellow matter, which takes placein the congested centres of the hepatic lobules. (3) We haveobserved, particularly in the embryo of the fish, the developmentof pigment, and seen it commence by the appearance of a minutefret particle of intense blackness, smaller than a nucleus, close by. Branched connective-tissue corpns-clesj from the pia mater of upperpart of spinal cord, containing muchpigment. The specimen was froma case of Addisons disease, but only-showed an exaggeration of thenormal pigmentation of the part.(From an original i^reparation.) MELAIs^OSIS AND MELANOTIC TUMOURS. 163 tlie side of a vessel; so also in the abundant formation of blackpigment which takes place in the liver of the frog at certain timesthere is not the least reason for regarding it as specially derivedfrom the red colouring matter of the globules, but much more forsupposing it to proceed from some of the highly carbonized matterscontained in the liquor sanguinis. Small particles of coal, having the peculiar Spitted structureof coniferous wood, have been found in the interior of the lungs ofcoal workers by Traube. It has, however, been shown that theoccurrence of minute haemorrhages is another cause of the pig-mentation of lungs.* In this instance, as in man
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