. The endocrine organs; an introduction to the study of internal secretion . ine Organs arterial pressure (J. D. Cameron). Moore and Purinton found that with very minutedoses a fall of pressure may be obtained instead of a rise. If the amount injected isconsiderable, the rise of blood-pressure caused by vascular contraction and heartacceleration may be enormous—three or four times the normal—and the amount ofstrain put on the heart is correspondingly great. Sometimes the heart muscle is\inable to respond properly xinder these circumstances and the ventricular actionbecomes fibrillar—delirium c
. The endocrine organs; an introduction to the study of internal secretion . ine Organs arterial pressure (J. D. Cameron). Moore and Purinton found that with very minutedoses a fall of pressure may be obtained instead of a rise. If the amount injected isconsiderable, the rise of blood-pressure caused by vascular contraction and heartacceleration may be enormous—three or four times the normal—and the amount ofstrain put on the heart is correspondingly great. Sometimes the heart muscle is\inable to respond properly xinder these circumstances and the ventricular actionbecomes fibrillar—delirium cordis being produced, generally leading to instantdeath. This seems especially liable to occur in a particular phase of early chloro-form anaesthesia (Levy). As a general rule a number of successive injections can be made into a vein, andeach one will produce an amount of rise of blood-pressure proportionate to theamount of autacoid in the extract: the activity can in fact be gauged by thismethod. Other modes of testing the activity of suprarenal extracts are (1) by. FIG. 39.—Etlect of solution of adrenalin upon an isolated portion of uterus of rat. The contractions are inhibited. their action when added to Ringers solution perfused through the blood-vessels ofa frog the central nervous system of which has been destroyed, (2) by the effectproduced upon the pupil of the excised eye of a frog when immersed in Ringerssolution to which a definite amount of the extract is added, (3) by immersion of theexcised uterus of a rat in a similar solution kept aerated by a stream of oxygen andmaintained at body temperature, (4) the same, using a piece of intestine insteadof uterus, and (5) the same, using strips of artery cut transversely. The effect of suprarenal extract upon the heart and vessels is not theonly action upon plain muscle, although it is the most obvious. Other-involuntary muscular tissue supplied by sympathetic fibres is also may be in the direction of
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