. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. Specific Organism 773 it is of interest to know that Wood* has been able to collect nine such cases from the literature. Specific Organism.—The cause of the disease was unknown until the discovery of Treponema pallidum, which opened a way for its investigation. Castellani* was quick to seize the opportunity, and in the same year in which Schaudinn and Hoffmann discovered the cause of syphilis, announced a similar organism as the cause of yaws. At the tim
. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. Specific Organism 773 it is of interest to know that Wood* has been able to collect nine such cases from the literature. Specific Organism.—The cause of the disease was unknown until the discovery of Treponema pallidum, which opened a way for its investigation. Castellani* was quick to seize the opportunity, and in the same year in which Schaudinn and Hoffmann discovered the cause of syphilis, announced a similar organism as the cause of yaws. At the time of discovery he called it Spirochseta pertenuis and Spirochaeta pallidula, but it is now recognized as a treponema and is called Treponema pertenue. Morphology.—The organism so closely resembles Treponema pallidum that it is rather by knowing the source from which the organism was derived than by any morphologic distinctions that. Fig. 304.—Yaws (photograph by P. B. Cousland, M. B., Swatow, China). the two are separated. It is said to be a little shorter than T. pallidum, measures 7 to 20 ^ in length, is closely and regularly coiled, and is said to have rounded ends. Staining.—^It stains like its close relative, palely with most of the dyes. The silver nitrate, the India ink methods, and the other methods of staining Treponema are all appropriate, both for demonstrating it in smears from the lesions or in sections of tissue. Cultivation.—The organism seems not yet to have been cultivated. Pathogenesis.—Castellanif has succeeded in infecting monkeys with the scrapings from yaws papules. The infection usually re- sulted in a local lesion, though there was also a generalized infection, for he found treponemata everywhere in the lymph-nodes. When the inoculation material was filtered and all of the organisms re- *"Brit. Med. Jour.," 1905, 11, 282, 1280, 1330. t "Jour, of Hygiene," 1907, vii, p. Please note that these images are extracted from
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