A textbook of obstetrics . Ruysch(1691) and Albinus (1754), that theexistence of innumerable little cystsin the uterus and their final expulsionwere dependent upon some diseaseor alteration of the ovule, becameat last generally adopted. A moredefinite explanation, however, was notattempted until, in the early part ofthis century, it was claimed by Percy,3Cloquet,4 and Mme. Boivin 5 that thevesicular disease depended upon thepresence of echinococci. Velpeau 6was the first to indicate that thecysts were nothing but the dis-tended chorion villi,—a fact that wassoon acknowledged to be indisput-abl
A textbook of obstetrics . Ruysch(1691) and Albinus (1754), that theexistence of innumerable little cystsin the uterus and their final expulsionwere dependent upon some diseaseor alteration of the ovule, becameat last generally adopted. A moredefinite explanation, however, was notattempted until, in the early part ofthis century, it was claimed by Percy,3Cloquet,4 and Mme. Boivin 5 that thevesicular disease depended upon thepresence of echinococci. Velpeau 6was the first to indicate that thecysts were nothing but the dis-tended chorion villi,—a fact that wassoon acknowledged to be indisput-able. Since Velpeaus announcement, cystic degeneration of the villi has been attributed to hypertrophyand edema (Meckel, Gierse) ; to disease of the blood-vessels(Bartolin, Miller, Cruveilhier) ; to disease of the lymphatics (Bid-los, Sommerring) ; to degeneration of the mucous substance withinthe villi, continuous with the substance of the cord (Virchow) ;to a degeneration of the epithelial cells derived from the decidua,. Fig- 77- — Cystic disease(myxoma) of the chorion; hy-datidiform mole. 1 See Tarnier et Budin, p. 299. 2 See the interesting quotation by Priestley {loc. cit., p. 36) from AmbroisePare, that the Countess Margaret brought forth at one birth 365 infants, whereofiNj were said to be males, as many females, and the odd one a hermaphrodite (1276 A. 1). ). 3 Jour, de Med., t. xxii. p. 171, l8ll. 1 \o. 1, De la Faune des Med., Priestley. 5 Nouvelles Recherches sur le Mole vesiculate. broch., Paris, 1N27. 6 l)e lArt des Accouchements. io6 PREGNANCY. which replace the epithelial covering (exochorion) of the chorion(Ercolani); and, finally, to a pathological hyperplasia of thesyncytium. Virchows l explanation is that thechange resultingin the cystic degeneration of the chorion villi takes place altogetherm the endochorion, which forms the inner of the two layers thatcompose the chorion and is continuous with the Wharton jellyof the umbilical cord; this change consists
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