. Electron microscopy; proceedings of the Stockholm Conference, September, 1956 . Fig. L Semi-diagrammatic representation of the general structure of the lung alveolus. 1, capillary endothelium; 2, cytoplasmic layer: .?, septal space: 4, vitreous basement membrane; 5, endothelial ceil junction: 6, intraseptal cell; 7, alveolar cells (large, small and free); 8, collagen fibrils; 9, elastic fibers. On the other hand, evidence is presented on the pathological changes of these elements under the action of an irritating process. Rats narcotised with Nembutal were injected intra- tracheally with Pal
. Electron microscopy; proceedings of the Stockholm Conference, September, 1956 . Fig. L Semi-diagrammatic representation of the general structure of the lung alveolus. 1, capillary endothelium; 2, cytoplasmic layer: .?, septal space: 4, vitreous basement membrane; 5, endothelial ceil junction: 6, intraseptal cell; 7, alveolar cells (large, small and free); 8, collagen fibrils; 9, elastic fibers. On the other hand, evidence is presented on the pathological changes of these elements under the action of an irritating process. Rats narcotised with Nembutal were injected intra- tracheally with Palade mixture. Small pieces of tissue were fixed for 2 hours and embedded in prepolymerised butyl methacrylate containing 1 per cent benzoyl per- oxide. Sectioning was done by means of a Porter micro- tome. An RCA EMU 3A electron microscope was used. The relations between the cytoplasmic alveolar lining and the large cells are rather peculiar. The large alveolar cell is partly capped, sometimes on a great length (5 microns) by the cytoplasmic layer. The large alveolar cell is then set in the prolongations of the small cells and if the observer could look at the front, only a part of its front surface would be seen. It will be noted that the microvilli of the large alveolar cell appear only at the extremity of the cytoplasmic lining. The boundary between the two cellular surfaces seems to be the continuation of the basement membrane which inserts the cytoplasm. It is thought that they probably have the same mucopolysaccharidic nature. The appearance of the mitochondria is variable. Cristae are numerous and sometimes pressed close together. Their aspect varies according to the orienta- tion of the section. Images of tubules in cross-section
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