Interstate medical journal . f undestroyed bone. Albumose, giving the Bence Jones reaction, has been found by Coriatin pleuritic effusion, while in this case it was absent from the urine. Boston considers the reaction which is most reliable to be that withlead acetate and caustic soda for the detection of sulphur. Many chemistsreport that loosely combined sulphur is a pre-eminent feature which dis-tinguishes Bence Jones albumose from other albumoses. CALE: BENCE JONES ALBUMOSURIA 397 The most prominent characteristic of the Bence Jones albumose is itscoagulability at or near 50° C.; the slower
Interstate medical journal . f undestroyed bone. Albumose, giving the Bence Jones reaction, has been found by Coriatin pleuritic effusion, while in this case it was absent from the urine. Boston considers the reaction which is most reliable to be that withlead acetate and caustic soda for the detection of sulphur. Many chemistsreport that loosely combined sulphur is a pre-eminent feature which dis-tinguishes Bence Jones albumose from other albumoses. CALE: BENCE JONES ALBUMOSURIA 397 The most prominent characteristic of the Bence Jones albumose is itscoagulability at or near 50° C.; the slower the heat is applied to the testtube the heavier the precipitate. The point of coagulability is muchbelow that of serum albumin or egg albumin, and is the reason attentionwas first called to the peculiar urine of the case to be reported. In the true sense the albumose is not coagulated by heat and acids, butrather precipitated, for upon boiling the precipitate disappears or is re-dissolved and reappears as the liquid Fig. 2. Soft parts of arm removed, showing destruction of bone (b) shown in Fig. 1. A precipitate is formed upon the addition of cold nitric acid to urinecontaining this substance which is redissolved on boiling and reappearswhen the liquid is cooled. Similar results are obtained with hydro-chloric and sulphuric acids. If acid urine is neutralized with sodium or ammonia no precipitationresults. If acetic acid be added to the urine, heat will not precipitate thealbumose. 398 INTERSTATE MEDICAL JOURNAL If a saturated solution of sodium chloride be added to the urine whichcontains acid, complete precipitation will take place on heating, but inthis instance the precipitate is not redissolved upon boiling. If alcohol be added to the urine in the proportion of two to one,precipitation occurs; this precipitate is insoluble. Picric acid produces a precipitate which does not dissolve upon boiling. Formalin added to the urine produces at first a very slight cloudine
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