Pompe disease is a rare hereditary disease characterized by the deficiency of an enzyme called acid alpha-glucosidase (GAA). One of the main features of Pompe disease is the progressive breakdown of communications between nerve and muscle cells. This image is of a leg muscle (tibialis anterior) from an adult mouse model of Pompe disease. Nerve cells (green) and cellular nerve-muscle communication sites, called neuromuscular junctions, (red) are fluorescently labeled to observe the continued deterioration of neuromuscular junctions.

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Photo credit: © NIH / IMAGE POINT FR / BSIP / Alamy / Afripics
License: Licensed
Model Released: No

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