A reference handbook of the medical sciences, embracing the entire range of scientific and practical medicine and allied science . mahgnancy is very mild. MacroscopicaUy the tissue is transparent and gela-tinous, the surface of a section of the tumor being notinaptly likened to the interior of a grape or plum. become involved in the carcinomatous process; andin no instance coming under his observation didcarcinoma appear as a primary lesion, but alwayssecondarily in the gland substance close to, but witha distinct bridge of apparently healthy tissue sepa-rating it from, the original sk
A reference handbook of the medical sciences, embracing the entire range of scientific and practical medicine and allied science . mahgnancy is very mild. MacroscopicaUy the tissue is transparent and gela-tinous, the surface of a section of the tumor being notinaptly likened to the interior of a grape or plum. become involved in the carcinomatous process; andin no instance coming under his observation didcarcinoma appear as a primary lesion, but alwayssecondarily in the gland substance close to, but witha distinct bridge of apparently healthy tissue sepa-rating it from, the original skin affection. Thus thefirst conception of the pathology was that the primaryskin affection represented the same precancerousstate of the epidermis that is seen in the paraffinand the chimney sweep types of cancer, or similarto keratosis of old age, and which, at first localizedon the nipple and areola, finally extended to theducts and acini of the gland and progressed as a mildform of cancer. A more accurate definition byCumston is, that it is a chronic pathological processof the skin of the areola and nipple associated with. Fig. 1129.—Pagets Disease of the Nipple. ,Alt-T Ijrdyce; Mudd, .\m. Practice of Surgery.) 4. M.\LIGN.^NT PaPILL.^RY DERMATITIS (PaGEts DisE.\SE OF THE Nipple).—This is a rare, chronicaffection of the nipple and areola, eventuating incarcinoma of the mammary gland, and known bythe name of its author, Sir James Paget, who firstbrought it to the notice of the profession in 1874. The pathology of this disease has been one of thevexed questions in medicine, but now the majorityof pathologists have about definiteh assigned it tothe ranks of the carcinomas. It was described byPaget as an eruption—a chronic eczema—beginningon the nipple and areola which continued to bear thecharacters of such even after the affected skin had 488 carcinoma in the breast gland. Jacobaeus assertsthat the cancer may exist either as a superficialspongy mass in the retracted nip
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