. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R28. LABORATORY OF BARBARA FURIE AND BRUCE FURIE |Pub/ications Brown, M., B. Hambe, B. Furie, B. C. Furie, J. Stenflo, and L M Stenberg. 2002. Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for p- carboxyglutamic acid, lexicon 40: 447-453, Czerwiec, E., G. S. Begley, J. Stenflo, K Taylor, B. C. Furie, and B Furie. 2002. Structural similarity and functional differences between invertebrate and vertebrate carboxylases: expression and character- ization of recombinant vitamin K-dependent
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. R28. LABORATORY OF BARBARA FURIE AND BRUCE FURIE |Pub/ications Brown, M., B. Hambe, B. Furie, B. C. Furie, J. Stenflo, and L M Stenberg. 2002. Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for p- carboxyglutamic acid, lexicon 40: 447-453, Czerwiec, E., G. S. Begley, J. Stenflo, K Taylor, B. C. Furie, and B Furie. 2002. Structural similarity and functional differences between invertebrate and vertebrate carboxylases: expression and character- ization of recombinant vitamin K-dependent (J- glutamyl carboxylase from Conus textile. £ur. J. Biochem. 269:6162-6172. Cone snails, Volker Steger P-Carboxyglutamic acid is a calcium-binding amino acid that is found in the conopeptides of the predatory marine cone snail, Conus. This laboratory has been investigating the biosynthesis of this amino acid in Conus and the structural role of p-carboxyglutamic acid in the conopeptides. This satellite laboratory relates closely to the main laboratory, the Center for Hemostasis and Thrombosis Research, on the Harvard Medical School campus in Boston, whose main focus is the synthesis and function of p-carboxyglutamic acid in blood clotting proteins and the role of vitamin K. [Staff ADJUNCT SCIENTISTS Barbara C. Furie. Harvard Medical School Bruce Furie, Harvard Medical School Alan Rigby, Harvard Medical School VISITING SCIENTIST Johan Stenflo, University of Lund STAFF SCIENTIST II Eva Czerwiec Until recently, the marine cone snail had been the sole invertebrate known to synthesize the vitamin K-dependent amino acid, p-- carboxyglutamic acid (Gla), but the work of this laboratory and others has shown that this synthetic pathway has been preserved in most animal phyla. The cone snail produces neurotoxic conopeptides, some rich in Gla, which it injects into its prey to immobilize it. To examine the biosynthetic pathway for Gla, we have studied the Conus carboxylase which converts
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