. Poisons; their effects and detection; . grms. per kilo. Strychnine kills 3 06 times more quicklythan brucine, the intensity of the action of strychnine relative to that of * Journ. Physiol., viii. 393-403. t Brucinu. Strychnin ; cine toxilcolorjische ParalleU, von Dr. F. A. Falck. Viertel-jahrsschr. f. cjcrichtl. Med., Band xxiii. p. 78. 342 POISONS: THEIE EFFECTS AND DETECTION. [§ 403- brucine being as 1 : 1174. Falck has also compared the minimum lethaldose of strychnine and brucine with the tetanising opium alkaloids, asshown in the following table :— TABLE SHOWING THE LETHAL DOSES OF VAR
. Poisons; their effects and detection; . grms. per kilo. Strychnine kills 3 06 times more quicklythan brucine, the intensity of the action of strychnine relative to that of * Journ. Physiol., viii. 393-403. t Brucinu. Strychnin ; cine toxilcolorjische ParalleU, von Dr. F. A. Falck. Viertel-jahrsschr. f. cjcrichtl. Med., Band xxiii. p. 78. 342 POISONS: THEIE EFFECTS AND DETECTION. [§ 403- brucine being as 1 : 1174. Falck has also compared the minimum lethaldose of strychnine and brucine with the tetanising opium alkaloids, asshown in the following table :— TABLE SHOWING THE LETHAL DOSES OF VARIOUSTETANISING POISONS. Minimum Lethal Dose for every Proportional Kilogram Weight Strength. of Eabbit. Mgniis. Strychnine nitrate, 0-6 Thebaine nitrate, 14-4 24-0 Brucine nitrate, 23-0 38-33 Landanine nitrate, ..... 29-6 49-33 Codeine nitrate, 51-2 85-33 Hydrocot-arnine nitrate, .... 203-8 339-66 If these views are correct, it follows that the least fatal dose for anadult man would be 1-64 grm. (about 24*6 grains) of brucine Brucine Crystals. {From a Plwtograph.) § 403. Tests.—If to a solution of brucine in strong alcohol a littlemethyl iodide is added, at the end of a few minutes circular rosettes ofcrystal groups appear (see fig.): they are composed of methyl brucineiodide (C23H25(CH3)N204lII). Crystals identical in shape are alsoobtained if an alcoholic solution of iodine, or hydriodic acid with iodine,is added to an alcoholic solution of brucine. A solution of strychninegives with methyl iodide no similar reaction. Strychnine in alcoholic § 403-] BRUCINE. 343 solution, mixed with brucine, in no way interferes with the test. Themethyl iodide test may be confirmed by the action of nitric acid. Withthat reagent it produces a scarlet colour, passing into blood-red, intoyellow-red, and finally ending in yellow. This can be made somethingmore than a mere colour test, for it is possible to obtain a crystallinebody from the action of nitric acid on brucine. If a l
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectpoisons, bookyear1895
