. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. 188 BIOLOGY OF THE LABORATORY MOUSE hyperchromatic, oval nuclei and scant cytoplasm. The stroma consists of loosely scattered, threadlike connective tissue cells and thin-walled blood vessels. This type of tumor derives its name from its manner of growth, which is intraductal, filling the lumen with wildly growing, epithelial tumor cells, but having an outer layer of orderly arranged cells. This arrangement of cells, together with the manner of infiltrating the stroma in branching finger-like. Lumen
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. 188 BIOLOGY OF THE LABORATORY MOUSE hyperchromatic, oval nuclei and scant cytoplasm. The stroma consists of loosely scattered, threadlike connective tissue cells and thin-walled blood vessels. This type of tumor derives its name from its manner of growth, which is intraductal, filling the lumen with wildly growing, epithelial tumor cells, but having an outer layer of orderly arranged cells. This arrangement of cells, together with the manner of infiltrating the stroma in branching finger-like. Lumen Epithelial tumor cells Fig. ioo.—Macroglandular adenocarcinoma of the mammary gland (X200). processes, constitutes the distinguishing characteristics for intracanalicular adenocarcinoma. Mitoses are frequent. Infiltration of normal adjacent structures occurs and metastases to the lungs are fairly frequent. Macroglandular adenocarcinoma.—This type of growth is probably what Apolant (i) called fissure forming carcinoma of the mammary gland. Here occurs what appears to be enormous gland-like structures with long, branch- ing, irregular lumena (Fig. 100). The walls are thrown into folds and are composed of four or five to many cell layers in thickness. The epithelial tumor cells forming the walls are medium sized, oval and closely packed, often growing in wild disorder with frequent mitotic figures in Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Roscoe B. Jackson Memorial Laboratory; Little, Clarence C. (Clarence Cook), b. 1888; Snell, George D. (George Davis), 1903-; Dingle, John H. (John Holmes), 1908-. Philadelphia, The Blakiston company
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