. The thyroid gland in health and disease. cessation and the dis-charge of the fcjetus from the This finding is of theutmost importance, not only in regard to its bearing on the genesisof congenital goitre, but also as indicating what must be inmodern woman a frequent source of intra-uterine death of thechild. The frequency with which such an unfortunate eventoccurs in women who are sufferers from grave toxaemias iswell known, but it is not so generally recognized that bacteriainhabiting the intestinal tract may be a source of suchtoxaemias, 1 In these experiments, twelve goats fed on
. The thyroid gland in health and disease. cessation and the dis-charge of the fcjetus from the This finding is of theutmost importance, not only in regard to its bearing on the genesisof congenital goitre, but also as indicating what must be inmodern woman a frequent source of intra-uterine death of thechild. The frequency with which such an unfortunate eventoccurs in women who are sufferers from grave toxaemias iswell known, but it is not so generally recognized that bacteriainhabiting the intestinal tract may be a source of suchtoxaemias, 1 In these experiments, twelve goats fed on fsecal cultures throughoiitpregnancy, gave birth to eleven kids with congenital goitres. They were bornprematurely and all were hairless and ill-developed. The horny part of the hoofwas quite undeveloped. [25.] See Appendix.—R. McC. EXPERIMENTAL CONSIDERATIONS 119 As illustrating the effect of the toxic products of intestinalbacteria in producing tetanoid symptoms, an experiment whichI carried out on dogs, in 1911, may be of Fig. 51.—Experimentally-prodiiced atrophy in thyroid of dog ; note completeabsence of colloid except for one inspissated mass, disappearance of alveolarstructure, destruction and desquamation of cells, invasion by fibroblasts andcommencing formation of young fibrous tissue. X 500.
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