Tuberculin in diagnosis and treatment . emperature caused by the tuberculin assumes twoforms: one coming on at once; another, a secondary reaction,coming on a few days after the dose has been given. The risecoming on at once differs somewhat according to the preparationused. It comes on sooner with human tuberculin than withbovine. In the former it usually appears the same day if thedose is given in the morning; while with bovine it usually comeson the second day. As a rule, a rise which starts two or threehours after an injection is not due to the remedy, although wesee it beginning very ofte
Tuberculin in diagnosis and treatment . emperature caused by the tuberculin assumes twoforms: one coming on at once; another, a secondary reaction,coming on a few days after the dose has been given. The risecoming on at once differs somewhat according to the preparationused. It comes on sooner with human tuberculin than withbovine. In the former it usually appears the same day if thedose is given in the morning; while with bovine it usually comeson the second day. As a rule, a rise which starts two or threehours after an injection is not due to the remedy, although wesee it beginning very often about eight, and sometimes six andeven four, hours after the dose has been administered. Another characteristic of this curve is that it does not reachits normal on the morning of the second day (Fig. 22). If a TEMPERATURE CURVE IN TUBERCULOSIS. 149 fever reaction occurs on one day as a result of an injection oftuberculin, the early morning temperature on the succeeding dayis nearly always above the normal for that time of day. While. Fig. 22.—Illustrating three different curves representing tuberculin reactions. It willbe noted that the temperature does not return to normal on the second day of thereaction. This is quite characteristic of the curve of tuberculin reactions. Timeof dose is marked by x. this occurs in other conditions which produce rise of temperature,it is the rule after tuberculin. The secondary reaction usually comes on a few days after 80 90 : : : ^ 80 Wffi [ji 14 [1| [] \\^y\ 1^^144 rrnJT A-\ 0 95 10 ^ Fig. 23.—Illustrating a secondary tuberculin reaction. The dose of tuberculin was givenon the day indicated by the cross. Temperature showed only a slight rise the sec-ond day, but did not reach its maximum until the third, fourth, fifth, and sixth will be noticed that this rise designated as a secondary reaction is similar to therise that often occurs in active tuberculosis (see Fig. 24) as a result of inflammationin the tuberculous areas. It is
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