. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. :m. invasive methods to analyze dynamic birefringence of meiotic spindles (Pol-Scope) and to study transmembrane ion and gas transport (self- referencing electro-physiological techniques). Specifically, both approaches are yielding new insights into the pathophysiology of apoptotic cell death in oocytes and embryos, which occurs during maternal aging and after exposure to some environmental toxicants. Our laboratory also studies the role of telomeres on developmental competence of oocytes and embryos. Using a transgenic mous
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. :m. invasive methods to analyze dynamic birefringence of meiotic spindles (Pol-Scope) and to study transmembrane ion and gas transport (self- referencing electro-physiological techniques). Specifically, both approaches are yielding new insights into the pathophysiology of apoptotic cell death in oocytes and embryos, which occurs during maternal aging and after exposure to some environmental toxicants. Our laboratory also studies the role of telomeres on developmental competence of oocytes and embryos. Using a transgenic mouse model, which is null for the enzyme telomerase. and quantitative FISH to measure telomere length, we have demonstrated telomere shortening, aneuploidy. apoptosis. and cell cycle arrest after exposure to reactive oxygen species, generated pharmacologically or by some environmental toxicants with effects on mitochondria. Our laboratory makes extensive use of micromanipulation. including nuclear transfer technology. Ultimately, the Brown/Women and Infants Hospital Laboratory for Reproductive Medicine aims to translate studies on the pathophysiology of embryo development to produce clinical methods for assessing preimplantation embryo viability, an advance that will significantly contribute to the health of women and children. Staff Keefe, David, Director, Adjunct Scientist Liu. Lin. Adjunct Scientist Trimarchi. James. Adjunct Scientist Staff Rabinowitz, Michael. Associate Scientist Laboratory of Osamu Shimoimira Laboratory for Reproductive Medicine, Brown University and Women a;>d Infants Hospital, Providence Work in this laboratory centers on investigating cellular mechanisms underlying female infertility. Particular emphasis is placed on the physiology, morphology, and genetics of the oocyte .ind early embryo, with the aim of assessing the effects of maternal aging and of environmental toxicants on oocyte and embryo developmental potential. Studies taking place at the MBL b
Size: 2774px × 901px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
