. The chemistry of the injured cell. Cytochemistry; Pathology, Cellular. Fa ts 25 catalyses the union of cytidine-diphospho-choline and diglyceride with the production of lecithin. In this form most of the fat of the normal liver, and quite likely of other, cells is stored until required for metabolic purposes; much is liberated from the cells of the liver for utilisation and storage elsewhere in the body. These mechanisms, which are encountered both in living cells and isolated enzyme systems, are summarised in the scheme of Kennedy (1957) to whom we owe so much of this information. ATP + Gly
. The chemistry of the injured cell. Cytochemistry; Pathology, Cellular. Fa ts 25 catalyses the union of cytidine-diphospho-choline and diglyceride with the production of lecithin. In this form most of the fat of the normal liver, and quite likely of other, cells is stored until required for metabolic purposes; much is liberated from the cells of the liver for utilisation and storage elsewhere in the body. These mechanisms, which are encountered both in living cells and isolated enzyme systems, are summarised in the scheme of Kennedy (1957) to whom we owe so much of this information. ATP + Glycerol rOH hOH L0H -> a-glycerophosphate rOH â OH L0P Two Thioesters of Fatty Acid & CoA [2RC0-S-CoA] ATP + Choline 4 rFA Phosphatide Acid -FA L0P me Cytidine Cho Triphosphate Phosphate ->.Cytidine-diphospho' _. ., r. ^Diglyceride -FA L0H X7. Lecithin Fig. 1. The Biosynthesis of Phospholipid rFA Neutral Fat hFA LFA For choline there may be substituted ethanolamine or serine as happens during the biosynthesis of phosphatides in the brain and nerves by Schwann cells and probably oligodendroglial cells when they are laying down myelin sheaths around axones. In addition to these bio-syntheses there are important catabolic processes that make energy available to the cell. Fatty acids, for instance, are broken down to simpler carbon products as part of a process of oxidation which yields COo and water, with liberation of. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Cameron, Roy, Sir, 1899-1967; Spector, W. G. (Walter Graham). Springfield, Ill. , Thomas
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