. Gynecology : . is too powerful, there may result an excessive destruction and absorp-tion of the tissues. If the dose is insufficient, it may result in stimulating thegrowth to fresh activity. Harris summarizes the therapeutic value of radium by stating that itsefficacy depends: (1) Upon the amount used; (2) the amount and nature ofnitration; (3) the distance from the tumor tissue; (4) the length of exposure;(5) the resistance of the tissue, and (6) the number and length of exposures, asdetermined by the clinical judgment of the user. In a favorable case the local effect of radium on cancer
. Gynecology : . is too powerful, there may result an excessive destruction and absorp-tion of the tissues. If the dose is insufficient, it may result in stimulating thegrowth to fresh activity. Harris summarizes the therapeutic value of radium by stating that itsefficacy depends: (1) Upon the amount used; (2) the amount and nature ofnitration; (3) the distance from the tumor tissue; (4) the length of exposure;(5) the resistance of the tissue, and (6) the number and length of exposures, asdetermined by the clinical judgment of the user. In a favorable case the local effect of radium on cancer of the cervix is veryremarkable. The fetid discharge and odor ceases, bleeding stops, and thetumor masses and nodules rapidly melt away and disappear. In some cases,which before treatment seemed hopelessly inoperable, no sign of cancer can be 352 GYNECOLOGY detected by bimanual examination. Pain is often relieved immediately andcompletely. Favorable results of radium treatment are also seen in the early treatment. : ? Fig. 110.—Section of Cervical Cancer Removed by a Wertheim Operation After Treat-ment with had evidently been inserted in the cervical canal. The cancer cells near the cervicalcanal and in the interior of the cancer mass have been destroyed. The darker portions around theperiphery of the mass show the presence of active cancer cells. This is a drawing from a sectionmade at Wertheims clinic, and lent to the author by Dr. T. A. Ordway. of recurrences following radical operation, especially when the recurrence takesplace in the scar at the vault of the vagina. Unfortunately, all cancer cases of the cervix do not react in the satisfactory NEW GROWTHS 353 manner that we have described above. In certain far-advanced stages radiummay stimulate the growth to renewed activity of a most alarming nature,death being hastened by many months. This is in line with the observation ofSeuffert that the younger the cell, whether cancerous or normal, the moresensitive
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