Diseases of the nervous system .. . the white substance is also mark-edly involved in the sclerosis; it becomes thickened, as was previously stated,especially in the region of the adventitia. E. CHRONIC POLIOMYELITIS As acute poliomyelitis represents a particular form of acute myelitis, sochronic myelitis is typical of another special form, chronic poliomyelitis. There have been but few thorough investigations of this very rare disease(Oppenheim, Nonne and others), and its curability accounts for the veryexceptional occurrence of autopsies. The paralyzed muscles again resumetheir functions alt
Diseases of the nervous system .. . the white substance is also mark-edly involved in the sclerosis; it becomes thickened, as was previously stated,especially in the region of the adventitia. E. CHRONIC POLIOMYELITIS As acute poliomyelitis represents a particular form of acute myelitis, sochronic myelitis is typical of another special form, chronic poliomyelitis. There have been but few thorough investigations of this very rare disease(Oppenheim, Nonne and others), and its curability accounts for the veryexceptional occurrence of autopsies. The paralyzed muscles again resumetheir functions although a few remain weak; we are not fully cognizant ofthe histologic conditions. But the histologic findings obtained up to thepresent time very closely resemble those of the acute cases, in which theimplication of the medulla oblongata is prominent. Chronic poliomyelitis is, therefore, not limited to the spinal cord, and•the name poliomyelo-encephalitis would be much more 120 HISTOLOGY OF THE CENTRAL NERVOUS SYSTEM. Fig, 116.—Sclerotic Foci in the Spinal Cord,Staix. (After Oppenheim.) Weigerts F. MULTIPLE SCLEROSIS Multiple sclerosis is a peculiar form of clironic myelitis with typical his-tologic changes. It usually implicates the entire spinal cord as far as themedulla oblongata; isolated foci are not infrequently found also in the middleand inter-brain. From the onset the disease is chronic and focal. The situ-ation of the foci is entirely independent of the course of the fibers and the structure of the nervesubstance, sometimesbeino: only in the o-ravor in the white sub-stance ; occasionallythey occur in both, pass-ing from the white tothe gra}^ are distinctlyseparated from the nor-mal surroundings,show no sign of acutedestruction, of hemor-rhage, or of granular cells, and are in that stage of sclerosis which still showsnumerous cells: Glia proliferation, vascular thickening, increase of spinal cord in the medulla is permeated by
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