. Croonian Lecture: The Respiratory Process in Muscle and the Nature of Muscular Motion . as Hermann had found, and as all the text-books of theday described, was expected and looked for, but none was found; noincrease of carbon dioxide accompanied contraction unless the contractionwas forced by repeated strong stimulations to give marked fatigue. At rest again, the muscle in nitrogen gave a lower steady output of carbondioxide than in air; in oxygen ityielded carbon dioxide two or three times asfast (fig. 1). •30 6* .25 ?r: it: 1 «20 o U 6u •10 •05 r—i in airin oxygen beginning of oxygen+


. Croonian Lecture: The Respiratory Process in Muscle and the Nature of Muscular Motion . as Hermann had found, and as all the text-books of theday described, was expected and looked for, but none was found; noincrease of carbon dioxide accompanied contraction unless the contractionwas forced by repeated strong stimulations to give marked fatigue. At rest again, the muscle in nitrogen gave a lower steady output of carbondioxide than in air; in oxygen ityielded carbon dioxide two or three times asfast (fig. 1). •30 6* .25 ?r: it: 1 «20 o U 6u •10 •05 r—i in airin oxygen beginning of oxygen+ supply .to one cmsa sum Hours l 2fifter excision. 6 8 9 10 11 12 1 mn m& 22 23 24 25 28 1.—Survival discharge from crossed pairs of legs, one in air, the other in the Journal of Physiology, vol. 28, p. 354 (1902). 448 Dr. W. M. Fletcher and Prof. F. G. Hopkins. On contraction in oxygen, and now even, on slight contraction, it yielded theincrease of carbon dioxide expected by the text-books to be shown in air [(3) and tig. 2.] 1 OaY<$£/V //OfJ/?S AFTEf? Fig. 2.—Course of survival discharge of carbon dioxide from two crossed pairs ofgastrocnemii. Contraction periods are shaded. Temp. 17° C. (In the first contrac-tion period slow rhythmic stimuli were given and fatigue was not shown ; in thesecond period, rapid stimuli were given and the muscles were fatigued to a stand-still.) For details see the Journal of Physiology, vol. 28, p. 474 (1902). It may be said in passing that these results accorded with many observationsmade previously upon the whole animal in which conditions of imperfectoxygen supply had given apparent incompletion of oxidative processes, andexplained many earlier discordant observations made when blood was circulatedthrough muscle. It became clear then that the contemporary and immediate supply ofoxygen did affect the products due to contraction, and the inogen theory,postulating a previous inclusion of ox


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