Manual of pathological anatomy . fthe disease, nearly all the nerve fibres of the posterior columnsand posterior roots fall into a state of granular disintegration, andultimately disappear. Usually the posterior columns retain theirnormal size and shape in consequence of hypertrophy of the con-nective tissue, which replaces the lost fibres. In this tissue lieimbedded the remaining nerve fibres, with the debris of theirneighbours, in difierent stages of disintegration. Jn some placesthey are severed into short portions, or into rows of globularmasses, formed out of their medullary sheaths or wh
Manual of pathological anatomy . fthe disease, nearly all the nerve fibres of the posterior columnsand posterior roots fall into a state of granular disintegration, andultimately disappear. Usually the posterior columns retain theirnormal size and shape in consequence of hypertrophy of the con-nective tissue, which replaces the lost fibres. In this tissue lieimbedded the remaining nerve fibres, with the debris of theirneighbours, in difierent stages of disintegration. Jn some placesthey are severed into short portions, or into rows of globularmasses, formed out of their medullary sheaths or white substance,which has been stripped from their axis-cylinders. In otherplaces they have fallen into smaller fragments and granules, which * British Medical Journal, Jiily 3rd, 1869. 304 PARTIAL OR LOCALIZED INDURATION OF THE CORD, either lie aggregated in the line of the original fibres, or arescattered at irregular distances. Corpora amylacea and oilglobules are also seen; the latter often collected into groups round Fig. Section of spinal cord showing degeneration of posterior columns and part of posterior comua. (After Leyden.) the blood-vessels. In some cases the deeper central parts of thegrey substance are more or less injured by areas of disintegration ;but these latter lesions are not essential to the production oflocomotor ataxy. PARTIAL OR LOCALIZED INDURATION OF THE CORD. Sclerosis of particular regions or isolated foci occurs in the cordas in the brain. It differs from general sclerosis by the unequalknotted outline given to the cord, and further in its minutecharacters. It is, comparatively speaking, very rare. The hardsclerotic tissue contains a very large number of nuclei; and asimilar proliferation of nuclei or small cells may be seen in theouter coats of the smaller blood vessels. The interruption ofnervous currents thus caused may lead to secondary degenerationsafiecting considerable portions of the cord. This form of sclerosismay be regarded as analogo
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