. The endocrine organs; an introduction to the study of internal secretion . ct either hypoder-mically (G. Murray) or by the mouth (Mackenzie and Fox). Patientssuffering from the effects of loss of thyroid secretion, whether this take theform of cretinism, myxcedema, cachexia strumipriva, or endemic goitre,can be completely restored to health and kept normal for apparently anylength of time by buccal administration of the gland or its extracts(see figs. 18, 20, 22). If the treatment is intermitted the symptoms almostat once begin to reappear. The effects are therefore obviously due tothe loss
. The endocrine organs; an introduction to the study of internal secretion . ct either hypoder-mically (G. Murray) or by the mouth (Mackenzie and Fox). Patientssuffering from the effects of loss of thyroid secretion, whether this take theform of cretinism, myxcedema, cachexia strumipriva, or endemic goitre,can be completely restored to health and kept normal for apparently anylength of time by buccal administration of the gland or its extracts(see figs. 18, 20, 22). If the treatment is intermitted the symptoms almostat once begin to reappear. The effects are therefore obviously due tothe loss of an autacoid contained in the internal secretion. This autacoidin some way affects the metabolic processes of the body, either directly orindirectly promoting the nutrition of the connective tissues and influencingthe functions of the cells of the nervous system, particularly those of thecerebral cortex. 1 The alterations in metabolism in myxcedema and the effect of thyroid treatment uponthem have been studied in Tigerstedts laboratory by J. A. Andersson (Hygiea, 1898).. FIG. 21.—A case of post-operative myxoedema (cachexiastrumipriva) in a 26-year-old woman, (v. Brun.) Effects of Removal or Atrophy of Thyroid 33 Enlargement of the thyroid such as occurs in endemic goitre (fig. 22),in spite of a great increase in volume of the gland, is commonly attended
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