. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. OSMOTIC PROPERTIES OF THE ERYTHROCYT IV. Is THE PERMEABILITY OF THE ERYTHROCYTE TO DECREASED BY NARCOTICS? M. H. JACOBS AND ARTHUR K. PARPART (From the Department of Physiology, University of Pennsylvania and the Marine Biological Laboratory, Woods Hole, Massachusetts) I In the course of studies connected with his well-known " Haftdruck " theory, Traube (1908) made the observation that certain lipoid-soluble substances, such as amyl alcohol, which are also known to possess nar- cotic properties, may, under appropri
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. OSMOTIC PROPERTIES OF THE ERYTHROCYT IV. Is THE PERMEABILITY OF THE ERYTHROCYTE TO DECREASED BY NARCOTICS? M. H. JACOBS AND ARTHUR K. PARPART (From the Department of Physiology, University of Pennsylvania and the Marine Biological Laboratory, Woods Hole, Massachusetts) I In the course of studies connected with his well-known " Haftdruck " theory, Traube (1908) made the observation that certain lipoid-soluble substances, such as amyl alcohol, which are also known to possess nar- cotic properties, may, under appropriate conditions, exert an anti- hemolytic effect. This effect he interpreted as being due to " eine Ver- dickung der Lipoidschicht welche die Stabilitat der Blutkorperchen gegen andere Hamolytika andern ; A few years later Arrhenius and Bubanovic (1913) obtained similar results with chloroform, ethyl ether, ethyl and amyl alcohols, and benzene. As an example of these results one typical experiment with a hypotonic solution containing chloroform may be cited. In this experiment it was found after one hour at 37° C., followed by several more in the ice-box, that the per- centage of hemolysis decreased from 60 per cent in the absence of chloroform to a minimum of 37 per cent in the presence of per cent, rising again at higher concentrations. Arrhenius and Bubanovic did not hesitate to conclude that " diese Wirkung beruht vermutlich auf einer Verlangsamung des Eindringens von Wasser in die ; Among the more recent workers in this field, Yoshitomi (1920) found after exposures of 2 to 18 hours to hypotonic solutions, a lesser degree of hemolysis in the presence of certain concentrations of ether, chloro- form, chloretone and amylene hydrate than in their absence. He sug- gested that this effect might be due either to a less ready entrance of water into, or a more ready escape of salts from, the cells. Jarisch (1921) also obtained an inhibition of os
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