. Carbohydrate metabolism in rats with adrenocortical transplants. Adrenal cortex; Carbohydrates; Rats. In 1958, Reichstein' isolated a fifth cortin-active substance from a relatively inactive side fraction of an adrenal extract. This was named desoxycorticosterone. The common form of synthetic compound is desoxycorticosterone acetate. The structure of desoxycorticosterone is shown in figure 6. c=o. Fig. 6. Desoxycorticosterone Another substance believed to have cortin activity, but on which no data has been obtained, was isolated by Reichstein in the same fractionation experiment and is calle
. Carbohydrate metabolism in rats with adrenocortical transplants. Adrenal cortex; Carbohydrates; Rats. In 1958, Reichstein' isolated a fifth cortin-active substance from a relatively inactive side fraction of an adrenal extract. This was named desoxycorticosterone. The common form of synthetic compound is desoxycorticosterone acetate. The structure of desoxycorticosterone is shown in figure 6. c=o. Fig. 6. Desoxycorticosterone Another substance believed to have cortin activity, but on which no data has been obtained, was isolated by Reichstein in the same fractionation experiment and is called 17-hydroxydesoxycorticosterone. After separation of the first five named substances together . with many cortin-inactive steroids from the original cortical extract, there is remaining a cortin-active syrup which is usually referred to as the1 amorphous fraction'. This has chemical properties closely re- sembling those of the isolated crystalline hormones, solubility, specific ultraviolet absorption, et cetera. CH,OH 74. Reichstein, T. and J. Helv. Chim. Acta. 21: 1197. 1958. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Richardson, Philip Morrison, 1904-.
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