. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 50000 I03 DOSE ( SERUM MILLIEOUIVALENTS /ML OF SEA WATER ) FIGURE 1. Responses given by P. pugio to human serum and to certain serum proteins and glycogen. Regression lines were drawn from computed effective dose values obtained by Potency Probit Analysis. The potency (and 95% confidence limits) of low density lipoprotein (LDL) and alphai-globulins were () and () respectively. Potency X 100 equals percent of activity of total serum. Studies of stimulatory substances in human sent in Followin
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 50000 I03 DOSE ( SERUM MILLIEOUIVALENTS /ML OF SEA WATER ) FIGURE 1. Responses given by P. pugio to human serum and to certain serum proteins and glycogen. Regression lines were drawn from computed effective dose values obtained by Potency Probit Analysis. The potency (and 95% confidence limits) of low density lipoprotein (LDL) and alphai-globulins were () and () respectively. Potency X 100 equals percent of activity of total serum. Studies of stimulatory substances in human sent in Following ultrafiltration of human serum through a UM-2 membrane it was found that the retentate containing substances of greater than ea. 1000 MW was as active as the total serum. The ultrafiltrate containing smaller molecules was sig- nificantly less active and accounted for less than 20 per cent of the activity of the total serum. In human serum, proteins and glycogen are the major substances with molec- ular weights greater than 1000. Table I contains the results of bioassays of many of these substances together with the normal concentrations at which they occur in human plasma. All of the substances possessed a certain degree of response- inducing activity. When the concentrations tested are considered solely on the basis of mg per ml of sea water, the activities of five of the substances (alphai- globulins, orosomucoid, low density lipoprotein, very low density lipoprotein, and glycogen) are quite similar. The ED50 values of these five substances were esti- mated to range between ca. and mg per ml of sea water. Values for the other substances were considerably higher. Since there are, however, differences in the inherent concentrations of these various substances in serum itself, these differences must be considered in assessing the relative contribution that each sub-. Please note that these images are extracted from scanned page images that may have been digitally enhan
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
