Diseases of the nervous system : a text-book of neurology and psychiatry . diposogenifalis. This is characterized by aprogressive accumulation of fat throughout the body, chiefly showingabout the buttocks and breasts, and by a lack of development of theprimary and secondary sexual characters. Thus there is a stunting of the growth physical and mental, ahypoplasia genitalis, and a failure to develop the voice, the mammaeand the scrotum or testicle. As a rule there is a fairly persistent DISEASES OF THE HYPOPHYSIS—PITUITARY 163 though shght subnormal temperature, a marked degree of sugartoleranc
Diseases of the nervous system : a text-book of neurology and psychiatry . diposogenifalis. This is characterized by aprogressive accumulation of fat throughout the body, chiefly showingabout the buttocks and breasts, and by a lack of development of theprimary and secondary sexual characters. Thus there is a stunting of the growth physical and mental, ahypoplasia genitalis, and a failure to develop the voice, the mammaeand the scrotum or testicle. As a rule there is a fairly persistent DISEASES OF THE HYPOPHYSIS—PITUITARY 163 though shght subnormal temperature, a marked degree of sugartolerance, slowed pulse and a tendency to sluggishness or even sleepi-ness. Taper fingers are a contrasting picture to the pudgy ones ofacromegaly. Symptoms.—Neighborhood symptoms may also be observed as withthe acromegalic s3^mptoms. The optic nerve changes, bitemporalhemianopsia, are among the most important. Other symptoms of ageneral nature, as headache, nausea, vomiting, changes in the sellaturcica, etc., often occur, especially from tumors which destroy Fig. 56.—Typical tapering hand of adolescent hypopituitarism. Compare with Fig. 55.(From Cushings Pituitary Body.) It is by no means clear as yet whether the theory of a hormone isan adequate explanation. The theory of action through the vegetativenervous system is probably more satisfactory. Dyspituitarism.—Under this head, the majority of the anomaliesdue to disturbed pituitary structures may be gathered. These areincomplete forms of acromegaly and gigantism, cases of adiposity,alone or with genital atrophies, or genital anomalies, showing hy-])erfunction or hypofunction. Various epilepsies, probably condi-tioned by hydrocephalic changes are examples of dyspituitarism.\ariations in mental capacity are frequent, as well as a variety ofanomalies such as increased sugar tolerance or glycosuria; slightlysub- or supra-normal temperatures, polyuria, wakefulness, irritabilityand a group of character anomalies as
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