. Calcified tissues; proceedings. Bone; Collagen; Calcification. 230 B. E. C. NORDIN Dk Oestrodiol Tuj/day. 8 9 10 mg. daily a 57 yeai- The evidence regarding the effect of the androgens on calcium balance is rather scanty. Albright and Reifenstein (1948) were able to demonstrate the good effects of testosterone on several cases of osteoporosis but Ackerman et al. (1954) could find no effect at all. Henneman and Wallach (1957) considered that testosterone had some effect in senile men but no effect in women. Bartter (1957) reported an im- provement in calcium balance in one case of 1'' [ \
. Calcified tissues; proceedings. Bone; Collagen; Calcification. 230 B. E. C. NORDIN Dk Oestrodiol Tuj/day. 8 9 10 mg. daily a 57 yeai- The evidence regarding the effect of the androgens on calcium balance is rather scanty. Albright and Reifenstein (1948) were able to demonstrate the good effects of testosterone on several cases of osteoporosis but Ackerman et al. (1954) could find no effect at all. Henneman and Wallach (1957) considered that testosterone had some effect in senile men but no effect in women. Bartter (1957) reported an im- provement in calcium balance in one case of 1'' [ \^ osteoporosis on testosterone. Lafferty et al. (1964) reported that androgens and oestro- gens both reduced bone resorption in osteo- porosis but that after long administration a secondary decline in bone formation oc- curred. This is an interesting suggestion but unfortunately their method of calculating bone resorption rate is open to question. As far as the anabolic steroids are con- cerned the effect of these compounds on nitrogen balance is well established though it is not certain that the same effect could not be achieved in some instances at least by increased nitrogen intake. The effect on calcium balance is less consistent (Everse and Keep, 1961). There appears to be a fall in faecal calcium and sometimes a fall in urinary calcium but the overall effect on calcium balance is rather small and hardly comparable with that which can be achieved by high calcium feeding (Whedon, 1964). Dymling (1962) found no effect with an anabolic steroid on bone excretion rate and Gordan and Eisenberg (1963) had the same experience. Lund (1963) found at least as many cases of osteoporosis among steroid treated patients given an anabolic compound simultaneously as among those not given such supplementary therapy. Thus it would appear that reduction of oestrogenic activity (particularly when acute) may precipitate the reduction in bone volume which we call osteoporosis and that administra
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