. General surgical pathology and therapeutics, in fifty-one lectures .. . hese elements are much larger than lymph-cells, about thesize of cartilage-cells, or of moderately large flat epithelium, andusually have one or more large nuclei, with glistening nucleoli. Thecells are embedded in a fibrous, or more rarely homogeneous, slightly-developed intercellular substance of exquisite alveolar type, in such away that they lie together separately, or more rarely in groups ( and 139). They are most intimately connected with the fibres,and are difficult to detach from the fibrous mass. The la
. General surgical pathology and therapeutics, in fifty-one lectures .. . hese elements are much larger than lymph-cells, about thesize of cartilage-cells, or of moderately large flat epithelium, andusually have one or more large nuclei, with glistening nucleoli. Thecells are embedded in a fibrous, or more rarely homogeneous, slightly-developed intercellular substance of exquisite alveolar type, in such away that they lie together separately, or more rarely in groups ( and 139). They are most intimately connected with the fibres,and are difficult to detach from the fibrous mass. The latter two pe-culiarities are important for the histological diagnosis of sarcoma,for they show the large cells are connective-tissue cells, not epithelialcells, as in true carcinoma-tissue. Occasionally the cellular elementsof these sarcomata lie in immediate contact, without any intercellularsubstance; the resemblance to epithelial carcinoma may prove de-ceptive. Virchow has described and deduced this form from softwarts of the cutis. SARCOMATA. 651 Fie. 138. Fig. Alveolar sarcoma from the deltoid 400 diameters. Alveolar sarcoma from the 4)0 diameters. (f.) Pigmentary sarcoma. 3felanotic sarcoma. Melanoma. Allthese names indicate pigment formation in sarcoma. This pigment,which is usually granular, rarely diffuse, is brown or black, lies almostalways in the cells, rarely in the intercellular substance. Part or thewhole of the tumor may be faintly or distinctly black. Any of theabove forms of sarcoma may occasionally be pigmented, but I havemost frequently found this to be the case in the last form, and in thespindle-celled sarcoma. Melanomata develop most frequently in thecutis, especially of the foot and hand, but also on the head, neck, andtrunk. The arrangement of the cellular elements in sarcoma depends, onthe one hand, on certain directions of the fibres or fibre-cells in thetissue of the tumor; on the other, on the form of the vascul
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