. The thyroid gland in health and disease. acters ofthe parenchyma nuclei. Some are much enlarged, and may beeither deeply stained, hyper-chromatic or vesicular; thesenuclei are oval or spherical in outline, and may measure 8 to 10 /xin diameter. Others are small, intensely staining or pale-stain-ing ; these rejiresent recent-division forms. Others are irregular,kidney-shaped or pyriform. These diverse nuclear appearancesare the evidence of abnormal cell-division. Mitotic figures areoccasionally met with, especially in young glands. These HISTO-PATHOLOGY 63 changes have been observed in experi
. The thyroid gland in health and disease. acters ofthe parenchyma nuclei. Some are much enlarged, and may beeither deeply stained, hyper-chromatic or vesicular; thesenuclei are oval or spherical in outline, and may measure 8 to 10 /xin diameter. Others are small, intensely staining or pale-stain-ing ; these rejiresent recent-division forms. Others are irregular,kidney-shaped or pyriform. These diverse nuclear appearancesare the evidence of abnormal cell-division. Mitotic figures areoccasionally met with, especially in young glands. These HISTO-PATHOLOGY 63 changes have been observed in experimentally-produced goitrein rats [19]. 4. The cellular increase gives rise to an increased thickness ofthe acinar walls, to outgrowths of the epithelial lining formingbuds and plications of the acinar wall (figs. 10, 13, 14). 5. Thus the vesicles lose the comparative symmetry of theiroutline and become most irregular in shaj^e (figs. 14, 15, 16).The high columnar lining encroaches on the acinar cavities, andthese become relatively f^ Fig. 11.—Sectionoff thyroid gland showing experimentally-produced goitre inmouse, due to contamination of food with goitrous faeces. Early stage; noteabsorption of colloid, great increase in height and multiphcation of acinar epithe-lium, increased intervesicular tissue ; the vacuolation of the protoplasm of theacinar cells, due to the discharge of secretion, can be made out in some parts of thespecimen. X 166. 6. Many new acini are formed in the intervesicular tissue(figs. 12, 13). 7. In artificially-produced goitre in the rat granular massesof intensely staining basophil granules, lying in the intervesiculartissue, are conspicuous objects. They resemble masses of cocci,but are probably the granules of mast cells. 8. There is a greatly increased discharge into the lymphspaces and acini of thin gelatinous secretion from the heightened 64 PATHOLOGY epithelium ; it is very pale-staining. The edges of the epithelialcells often merge with th
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