Interstate medical journal . iodine and brominelesions investigated by us, as we feel that this subject, in a generalway, has been thoroughly discussed by others and that you are, nodoubt, familiar with it. As has already been mentioned, lesions in vari-ous stages of development, from the smallest prepapulo-pustular stage HISTO-IATHOLOGY AND THE THEORY OF DRUG ERUPTIONS. 857 to the large anthracoid variety, were included in our material. Thetissues were all fixed and hardened in alcohol, cut and mounted in cel-loidin, and stained by various methods. It is impossible to differentiatehistologica
Interstate medical journal . iodine and brominelesions investigated by us, as we feel that this subject, in a generalway, has been thoroughly discussed by others and that you are, nodoubt, familiar with it. As has already been mentioned, lesions in vari-ous stages of development, from the smallest prepapulo-pustular stage HISTO-IATHOLOGY AND THE THEORY OF DRUG ERUPTIONS. 857 to the large anthracoid variety, were included in our material. Thetissues were all fixed and hardened in alcohol, cut and mounted in cel-loidin, and stained by various methods. It is impossible to differentiatehistologically, as well as clinically, between iodide and the bromide produce an almost identical histological picture, differing only, possibly, very slightly in the finer technical details. When a section fromeither of these lesions is observed with a low power, the impression of adermatitis is at once conveyed. The epidermis is thickened, producedby intercellular and intracellular edema. There is some irritation of the. FlG. 4. Dilated capillary showing a later stage of the process, viz.: Increase ofconnective tissue cells, lymphocytes and engorgement of vessels with polynuclearleucocytes. epidermis, as here and there are seen evidences of mitosis. The thicken-ing of the epidermis is, however, chiefly produced by the cedema. Cours-ing through the cutis are large cellular cords, dilated blood vessels. Thecollagen is swollen and the areas of irritation have a hyalin or glazedappearance. The connective tissue cells are increased throughout thecutis. About the follicles and glands, on account of the increase of cellsabout their vessels, one sees a dense mass of newly formed cells. Deepin the cutis, and sometimes more superficially, we see dense groups ofcells, the beginning of an abscess. These dense groups of cells may occurabout a gland or follicle, or may be in no relation to them, as they often ENliMAN—MOOK. occur free in the center of the corium. In none of our sections
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectmedicine, bookyear190
