. Pharmaceutical bacteriology. Bacteriology; Disinfection and disinfectants. SEROLOGY—MANUFACTUK^ AND USE OF SERA AND VACCINES 265 probability, not enough antitoxin to neutralize the one hundred fatal doses of the toxin, and the eighth tube has, in all probability, a great excess of antitoxin. The contents of one tube is injected into a guinea-pig, thus requiring eight pigs. The animals are marked and kept under close observation. The first, second and perhaps third die, showing that not. enough serum was added to neutralize the toxin. The fourth pig just recovers, showing that the amount of s
. Pharmaceutical bacteriology. Bacteriology; Disinfection and disinfectants. SEROLOGY—MANUFACTUK^ AND USE OF SERA AND VACCINES 265 probability, not enough antitoxin to neutralize the one hundred fatal doses of the toxin, and the eighth tube has, in all probability, a great excess of antitoxin. The contents of one tube is injected into a guinea-pig, thus requiring eight pigs. The animals are marked and kept under close observation. The first, second and perhaps third die, showing that not. enough serum was added to neutralize the toxin. The fourth pig just recovers, showing that the amount of serum added to the fourth tube was sufl&cient to neutralize one hundred fatal doses of the toxin. This. Fig. 6s.—Guinea-pigs in wire cages. These lively little animals are used in test- ing the virulense of the diphtheria toxin which is injected into the horse and also for the purpose of standardizing the antitoxin. The reasons why these animals are pre- ferred are wholly bjological and physiological. They propagate rapidly, are easily kept easily handled, and respond (biologically) to the tests applied. amount of serum (antitoxic) represents one unit. From this amount or unit the quantities to be put into the containers are determined. 500, 1000, 2500 and 5000 unit quantities are put up, for the convenience of physicians. 500 to 1000 units constitute an immunizing dose, given to those who" do not have diphtheria, but who have been exposed to .the disease The larger doses are curative. The rule is to give large doses, repeated as often as may be necessary. 1000 units are usually em- ployed as immunizing doses; 3000, 5000 an^d ro,ooo unit packages for curative Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Schneider, Albert, 1863-1928. Philadelphia, P. Blakiston's Son & Co.
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Keywords: ., bookauthorschneide, bookcentury1900, bookdecade1920, bookyear1920
