. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 187 connective tissue and blood vessels infiltrate and can be found, by careful observation, even within the finer branches of the papillae which arc com- posed largely of disorganized nests and partial gland-forming foci of epithe- lial tumor cells. stroma Disorganized tumor cells Palisading layer. Fig. qq.—Intracanalicular adenocarcinoma of the mammary gland. A, shows typical architecture (X200); B, shows the cellular detail (X400). Intracanalicular adenocarcinoma.—Th


. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. SPONTANEOUS NEOPLASMS IN MICE 187 connective tissue and blood vessels infiltrate and can be found, by careful observation, even within the finer branches of the papillae which arc com- posed largely of disorganized nests and partial gland-forming foci of epithe- lial tumor cells. stroma Disorganized tumor cells Palisading layer. Fig. qq.—Intracanalicular adenocarcinoma of the mammary gland. A, shows typical architecture (X200); B, shows the cellular detail (X400). Intracanalicular adenocarcinoma.—This tumor grows as finger-like branching and anastomosing strands of epithelial tumor cells extending into a loose stroma (Fig. 99A). The edges of these strands are smooth due to an orderly paHsade arrangement of a single outer layer of epithelial cells. Within this palisade layer the entire remainder of these finger-like processes is composed of epithelial tumor cells of the same type and size but with a disorderly arrangement due to loss of normal orientation (Fig. 99B). These tumor cells are closely packed and cuboidal in shape, somewhat larger than normal resting mammar}^ gland epithelium, with moderately. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Roscoe B. Jackson Memorial Laboratory; Little, Clarence C. (Clarence Cook), b. 1888; Snell, George D. (George Davis), 1903-; Dingle, John H. (John Holmes), 1908-. Philadelphia, The Blakiston company


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Keywords: ., boo, bookcentury1900, bookcollectionbiodiversity, booksubjectmice