Phosphodiesterase enzymes (PDE) catalyze the degradation of cGMP, a molecular regulator of ion channels, cellular apoptosis (programmed cell death) an

---

Phosphodiesterase enzymes (PDE) catalyze the degradation of cGMP, a molecular regulator of ion channels, cellular apoptosis (programmed cell death) and smooth muscle tissue. In particular, drugs that inhibit PDE-5 have been successful in the treatment of erectile dysfunction. This figure shows a model vardenafil (Levitra) bonded to the active site of PDE-5, which includes a magnesium(2+) ion (pink) and a zinc(2+) ion (grey). For vardenafil the atoms are represented as spheres and are colour-coded: carbon (black), hydrogen (white), nitrogen (blue), oxygen (red) and sulphur (yellow).

---

Size: 5400px × 5400px
Photo credit: © GREG WILLIAMS/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

Keywords: 3d, 3d-render, biochemical, biochemistry, biological, biology, cgmp, chemical, chemistry, cut, cut-, cut-outs, cutout, cutouts, drug, dysfunction, ed, enzyme, erectile, inhibitor, levitra, medication, medicinal, model, molecular, molecule, outs, pde-5, phosphodiesterase, render, rendering, ribbon, space-filling, structure, sulfonamide, vardenafil, vinyl