. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. MODIFICATION OF RUNT DISEASE 363 the impending effects of runt disease in every case. Nevertheless, of 28 animals treated in this fashion 19 developed distinctly better than untreated controls, with those that died doing so at an 16 12 '10 Q 6 O OQ THREE DAY CELL INJECTION C57 spleen cells ^^^ sens, to DBA ^. Normal C57 spleen cells Second IV inj. (C57 BL/6 spleen cells) 4 6 8 10 12 14 16 18 20 24 DAYS OF LIFE 28 32 36 40 Fig. 10. Mean weight-gain curves of three litters of newborn C57BL/6 mice all of whic
. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. MODIFICATION OF RUNT DISEASE 363 the impending effects of runt disease in every case. Nevertheless, of 28 animals treated in this fashion 19 developed distinctly better than untreated controls, with those that died doing so at an 16 12 '10 Q 6 O OQ THREE DAY CELL INJECTION C57 spleen cells ^^^ sens, to DBA ^. Normal C57 spleen cells Second IV inj. (C57 BL/6 spleen cells) 4 6 8 10 12 14 16 18 20 24 DAYS OF LIFE 28 32 36 40 Fig. 10. Mean weight-gain curves of three litters of newborn C57BL/6 mice all of which received more than 10 million DBA/i spleen cells at birth. On the third day of Hfe four animals received an intravenous injection of about 15 miUion C57BL/6 spleen cells from adult donors which had previously rejected DBA/i skin grafts. The remaining five animals received a similar injection of normal adult C57BL/6 spleen cells on the same day. The former animals subsequently developed almost normally. The latter showed considerable delay before eventually reaching normal size. Controls from all htters which did not receive the second injection died of runt disease. average age of 3 5 days. Nine survived for over a hundred days and nine died promptly as though unaffected by the second cell injection. DBA/i skin grafts applied to the long-term survivors were rejected normally. An example of a htter in which a second. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on Transplantation (1961 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); Cameron, Margaret P. Boston, Little, Brown
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