Medical and surgical report of the Presbyterian Hospital in the City of New York . -SCLEROSIS OF ISLAND OF LANGERHANS. NORMAL SECRETINGPARENCHYMA (CASE XXXVIIH. FIG. 4—SCLEROSIS OF ISLAND OF LANGERHANS (CASE LXl) PATHOLOGICAL ANATOMY OF PANCREAS IN DIABETES MELLITUS. 177 increased. The lobulation was indistinct in some instances andin fifteen an infiltration of fat tissue was visible with the nakedeye. Neither cancer, cysts nor calculi of the pancreas were en-countered. There were no cases of pancreatic apoplexy. Microscopic Changes in the Pancreas. In considering the histological pathology of


Medical and surgical report of the Presbyterian Hospital in the City of New York . -SCLEROSIS OF ISLAND OF LANGERHANS. NORMAL SECRETINGPARENCHYMA (CASE XXXVIIH. FIG. 4—SCLEROSIS OF ISLAND OF LANGERHANS (CASE LXl) PATHOLOGICAL ANATOMY OF PANCREAS IN DIABETES MELLITUS. 177 increased. The lobulation was indistinct in some instances andin fifteen an infiltration of fat tissue was visible with the nakedeye. Neither cancer, cysts nor calculi of the pancreas were en-countered. There were no cases of pancreatic apoplexy. Microscopic Changes in the Pancreas. In considering the histological pathology of the pancreas indiabetes, it will be convenient to divide the subject into threeparts: (1) Changes in the interstitial tissue. (2) Changes in the glandular acini. (3) Changes in the islands of Langerhans. Changes in the Interstitial Tissue.—Chronic inflammation of thepancreas is a process w^hich is not confined to diabetes. Birch-Hirschfeld,^^ Schlesinger,^° Opie and others have described chronicinterstitial pancreatitis encountered in cases of congenitalsyphilis. Occlusion of the pancreatic ducts by calculi, newgrowths, or ligation, produces inmany


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Keywords: ., bookcentury1800, bookdecade1890, bookpublishernewyo, bookyear1896