. The Journal of laboratory and clinical medicine . Fig. 4.—Tracing showing decrease in tonicity of the pyloric sphincter as a result of vagus stimula-tion. Obtained from experiment 37, March 23, 1920; secondary coil at 8 cm.; ether for operation,records obtained under morphine, 10 mm. per kg. of dog. in nearly every case, but because of the increase in tonus and consequentlessened relaxation, the total excursion may be lessened at first. Frequentlythere is a spasm of the muscle which abolishes the rhythm entirely for a fewseconds. At least such would be inferred from the appearance of the rec
. The Journal of laboratory and clinical medicine . Fig. 4.—Tracing showing decrease in tonicity of the pyloric sphincter as a result of vagus stimula-tion. Obtained from experiment 37, March 23, 1920; secondary coil at 8 cm.; ether for operation,records obtained under morphine, 10 mm. per kg. of dog. in nearly every case, but because of the increase in tonus and consequentlessened relaxation, the total excursion may be lessened at first. Frequentlythere is a spasm of the muscle which abolishes the rhythm entirely for a fewseconds. At least such would be inferred from the appearance of the may be well to bear in mind the limitations of the apparatus and whatappears to be a spasm abolishing rhythm may very well be merely a contrac-tion of suf^cient force to obliterate the lumen of the balloon. Contractionoccurring beyond this point would fail to be recorded. However, perfectlyflat plateau traces such as would appear under these conditions are rareamong our records. NERVOUS CONTROL OF PYLORIC SPHINCTER 383. Fig. the effect of stumdation of the distal ^^^P/^,f ^ .^^f^^^^f tra^^^^on the of the pyloric sphincter, antrun,, and duodenum and the bW pre sue t^^^^^^^^^^^exoeriment ^ February 1, 1920; ether used throughout experiment; left splanchnic nerve stimuiateaecondary at 8 cm Trace 2, experiment 26, February 14, 1920; ether for operation, sodium veronalfoTowing operation. Left splanchnic stimulated, secondary at 14 cm. (Du Bois Raymond Coil.) Note similarity of responses of sphincter, antrum, and duodenum in both cases; also thatinhibition appears associated with marked vascular change, and that contraction is associated with aslight vascular effect. 384 THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE On the rhythm or frequency of the contractions, stimulation of the vagiproduces variable effects. A definite increase in the rate is a frequent result,especially when the rhythm has become very much slowed (Fig. 3). If the con-tracti
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