. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. Tropical Ulcer 533 tiple, as many as twenty sometimes occurring simultaneously. It is thought that recovery is followed by immunity. Organism.—In 1885 Cunningham* described a protozoan organ- ism found in the tropical ulcer, the observation being confirmed by Firth, t who called the bodies Sporozoa furunculosa. Later, J. H. WrightJ studied a case of tropical ulcer and found bodies pre- cisely like the Leishmania donovani. He gave it the name Hel- cosoma
. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. Tropical Ulcer 533 tiple, as many as twenty sometimes occurring simultaneously. It is thought that recovery is followed by immunity. Organism.—In 1885 Cunningham* described a protozoan organ- ism found in the tropical ulcer, the observation being confirmed by Firth, t who called the bodies Sporozoa furunculosa. Later, J. H. WrightJ studied a case of tropical ulcer and found bodies pre- cisely like the Leishmania donovani. He gave it the name Hel- cosoma tropicum. The great similarity to the other organisms has led more recent writers to identify it with Leishmania, but as it induces a local and not a general infection like kala-azar, it is now known as Leishmania furunculosa. Cultivation.—The organism has been Nicolle and. Fig. 221.—Oriental sore (Wellcome Research Laboratory). Manceaux§ upon the same media and in the same manner as Leishmania donovani and Leishmania infantum with which these investigators believe it to be identical. Cultivation was also success- fully achieved by Row. Pathogenesis.—The virus is pathogenic for man, monkeys such as Macacus simius, M. cynomolgus, M. rhesus and M. inuus, and for dogs. The same effects are produced whether fresh virus from a human ulcer, or from an artificial culture be employed. In dogs the inoculations produce only nodular formations; in monkeys, nodules like those in human beings that go on to ulceration. Intra- peritoneal inoculations usually fail. The most successful inocula- * "Scientific Memoirs by Medical Officers of the Army in India," 1884, i. t "British Med. Journal," Jan. 10, 1891, p. 60. I Jour, of Med. Research," 1904, x, 472. § Ann. de I'Inst. Pasteur," 1910, xxrv, Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appe
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