. The thyroid gland in health and disease. rk of fibroblasts, the meshesof which were filled with degenerating parenchyma cells. Colloidwas wholly absent except in a few scattered vesicles. Theseappearances are seen in fig. 51, and are well brought out bycomparison with the control animals gland (fig. 52). I did notat the time realize the importance of the observation, and failedto examine the parathyroids. [10.] With this preliminaxy consideration of the results of experi-ments in animals, we may now proceed to inqun-e how far theyaccount for the occurrence and course of the congenital mani-f
. The thyroid gland in health and disease. rk of fibroblasts, the meshesof which were filled with degenerating parenchyma cells. Colloidwas wholly absent except in a few scattered vesicles. Theseappearances are seen in fig. 51, and are well brought out bycomparison with the control animals gland (fig. 52). I did notat the time realize the importance of the observation, and failedto examine the parathyroids. [10.] With this preliminaxy consideration of the results of experi-ments in animals, we may now proceed to inqun-e how far theyaccount for the occurrence and course of the congenital mani-festations of the goitre noxa in the human subject. These mani-festations are : congenital goitre, cretinism, congenital hypo-thyroidism, and parathyroid disease. SECTION 3CONGENITAL GOITRE Congenital goitre is extremely common in villages where theendemicity of goitre is high. Thus, in certain Himalayan villages,where every woman and almost every man is goitrous, as higha percentage as 60 per cent, of cases of congenital goitre in breast-. Fig. 53.—Large congenital goitre in prematurely-born kid ; experimentally-produced. Mother fed on cultures of fsecal bacteria before and during pregnancy. fed infants has been found. [1.] It is interesting to note that thisfigure corresponds very closely to that found in experimentally-produced cases in rats (63 per cent.). 121 122 CONGENITAL GOITRE In such villages the percentage of abortion among women,and the infant mortality, are very high, so that the actual per-centage of cases born with goitre is probably considerably higherthan 60 per cent. In villages, on the other hand, where the endemicity of thedisease is lower, congenital goitre is not so common. The mothers of children born with congenital goitre are oftenmyxoedematous to some extent. They commonly suffer fromtetany. -».*a!i-:V!* .rv^^::;^-
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