. The endocrine organs; an introduction to the study of internal secretion . re concerned in governing the metabolism and mobilisation of those bodies, allthese organs being mutually interdependent. Of such organs the pancreas, pro-bably by virtue of the internal secretion of its islet tissue, may be regarded asoccupying the central position. The interrelations of these endocrine organs (particularly the thyroid, pancreas,and suprarenals) in connexion with the production of glycaemia and glycosuriahave been especially dwelt upon by Eppinger, Falta, and Rudinger. The relationsof the internal se
. The endocrine organs; an introduction to the study of internal secretion . re concerned in governing the metabolism and mobilisation of those bodies, allthese organs being mutually interdependent. Of such organs the pancreas, pro-bably by virtue of the internal secretion of its islet tissue, may be regarded asoccupying the central position. The interrelations of these endocrine organs (particularly the thyroid, pancreas,and suprarenals) in connexion with the production of glycaemia and glycosuriahave been especially dwelt upon by Eppinger, Falta, and Rudinger. The relationsof the internal secretion of the pancreas with glycogenic functions of the liver aredealt with at length by De Meyer, Secretion interne du pancreas, 1910. CHAPTER XVIII THE INTERNAL SECRETIONS OF THE GENERATIVEGLANDS IN THE MALE1 THE INTERSTITIAL CELLS OF THE TESTICLE IT was noticed by Leydig in 1850 that the intertubular connective tissueof the testicle is characterised by the presence of strands of epithelium-likecells; these have been termed the cells of Leydig, and, collectively, the ^. FIG. 90. —Section of testicle, human, showing groups of interstitial cells between the tubules. Magnified 50 diameters. interstitial gland of the testis. They vary in development in differentspecies of animals, being very well marked in the cat (fig. 92), less so inthe dog and mouse, and still less in the rat and rabbit: in man they maybe quite conspicuous (figs. 90, 91). The cells are always present to someextent, and Tandler and Grosz have shown that in animals which undergoseasonal changes in sexual activity the interstitial cells may be even betterdeveloped when the seminiferous tubules are inactive than during the time 1 For a fuller discussion of the subject of internal secretion in connexion with the sexualorgans, F. H. A. Marshalls Physiology of Reproduction may be consulted. 132 The Interstitial Cells of the Testicle 133 of their activity, their increased development generally immediately pre-cedin
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