. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . hing kgm., cc. adrenalin, 1:100,000caused a fall in blood pressure of per cent (from 123 mm.).After cutting the left brachial plexusthe same dose produced a fall in bloodpressure of per cent, (from 114mm.). Cutting the right brachial plexusreduced the fall to 9 per cent (from 100mm.), A cat weighing kgms. respondedto cc. adrenalin, 1:100,000 by an8 per cent fall in blood pressure (from150 mm.), and to cc. adrenalin,1:100,000 by an average fall of cent (4 injections). When bothbrachi
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . hing kgm., cc. adrenalin, 1:100,000caused a fall in blood pressure of per cent (from 123 mm.).After cutting the left brachial plexusthe same dose produced a fall in bloodpressure of per cent, (from 114mm.). Cutting the right brachial plexusreduced the fall to 9 per cent (from 100mm.), A cat weighing kgms. respondedto cc. adrenalin, 1:100,000 by an8 per cent fall in blood pressure (from150 mm.), and to cc. adrenalin,1:100,000 by an average fall of cent (4 injections). When bothbrachial plexuses and both femoral andsciatic nerves had been cut the per-centage fall from cc. adrenalin, „• r T>^ a ^ rig. 5. Blood pressure reac 1:100,000 was while from cc. tions to adrenalin ( cc, 1:100,-adrenalin, 1:100,000 the average fall (4 000) before and after cutting the •_•„„*• „\ ^„ no ^ (c 110 nerves to the limbs, a. Before; injections) was per cent (from 112 ^^ ^^^^^ Cat weighing kgms. mm.), (see fig. 5). (Reduced i). 360 FRANK A. HARTMAN AND LOIS MCP. FRASER The above doses were so small that the intestine would scarcely con-tribute to the fall in blood pressure. After dilatation in the limbs hadbeen prevented by destroying the central nervous connection therestill remained the important back, chest, shoulder and hip muscles,which easily accounts for the large percentage fall still obtained. On thewhole, this evidence tends to support our plethysmographic proof of acentral nervous function in adrenalin blood pressure fall. 2. By perfusion experiments A conclusive method of proving that the dilatation from adrenalinis due to a central nervous mechanism was devised. The part to bestudied, limb or intestine, was cut off from the body circulation andperfused with warm oxygenated Ringers solution. The nerves to thispart were left intact. Dilatation of the part was ascertained by eitherthe variation in outflow of the perfusing fl
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